Titanium alloy is widely used as a biomaterial due to its superior biocompatibility, mechanical properties close to human bones, and enhanced corrosion resistance. These properties have made the alloys suitable for use in a wide spectrum of biomedical applications including artificial bones, artificial joints, dental roots, and medical devices. The excellent performance of titanium alloy is mainly due to the oxide film as shown in Figure 1 [1]. The functional composition of the oxide film is mainly titanium dioxide (TiO2). Titanium dioxide has good biocompatibility, stable chemical property, and low solubility in water, which prevents substrate metal ions from dissolution. Furthermore, it also improves the wear and fatigue resistance of implants in the human body.
In summary, the Food Directorate's position is that there is no conclusive scientific evidence that the food additive TiO2 is a concern for human health. This is based on a review of the available scientific data relevant to food uses of TiO2. However, we will continue to monitor the emerging science on the safety of TiO2 as a food additive and may revisit our position if new scientific information becomes available.
Titanium dioxide has a number of unique characteristics that make it ideally suited to many different applications.
When asked about the recent Skittles lawsuit, the FDA said the agency does not comment on pending litigation.